Does BCG interact with other medications or foods?

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Bacillus of calmette and guerin (BCG) vaccine can interact with many medications, so you should tell your doctor about all prescription and over-the-counter (OTC) medications you take. The medications that interact with BCG include:

  • azathioprine, bleomycin, broxuridine, busulfan, capecitabine, carboplatin, cisplatin, 
  • daunorubicin, docetaxel, doxorubicin etanercept, floxuridine, fludarabine, fluorouracil, 
  • gallium nitrate, gemcitabine, hydroxyurea, idarubicin, irinotecan, methotrexate, 
  • oxaliplatin, paclitaxel, rituximab, sirolimus, tacrolimus, trimetrexate, uracil, vinblastine, and vincristine. 


Taking BCG along with abatacept and leflunomide may cause side effects, but it may be necessary to still take them during treatment with BCG.

Your doctor should instruct you about whether to take BCG with or without food or about foods you should avoid during treatment.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.