Are there medications to treat uterine fibroids?

Fibroids can be treated with medications including Lupron. These medications work to reduce the size of fibroids.

Dr. John C. Lipman, MD
Vascular & Interventional Radiologist

Yes. There are a number of medicines used to treat uterine fibroids.

The three most common medications used to treat fibroids are the following:

  • Non-steroidal anti-inflammatory medications (ex. ibuprofen). These help to reduce pain and bleeding. In, 2009, tranexamic acid was FDA approved as the first non-hormonal drug cleared for treating heavy menstrual bleeding. It has some specific effects on the uterine lining that results in more effective control of bleeding over other NSAIDs. Tranexamic acid is given only for the heavy bleeding days (up to 5) each month.
  • Oral contraceptive pills: Work to decrease bleeding through thinning uterine lining. Can stimulate fibroid growth and therefore may only be helpful for the short-term.
  • Gonadotropin-releasing hormone agonist (ex. Leuprolide aka Lupron): Suppresses ovarian function and induces a temporary menopausal state. Will shrink fibroids prior to surgery but can only be given for up to 6 months (usually given only 3) due to significant bone loss. Most women on Lupron get significant hot flashes which can make compliance difficult. If no surgery is performed, all of the Lupron effects wear off and the fibroids return to their original size.
Dr. Mehmet Oz, MD
Cardiologist (Heart Specialist)

A fibroid’s location is one of many factors affecting treatment options; among these, medications are sometimes used. Watch the video to learn more about treatment of fibroids.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.