Why does insulin resistance develop as people put on weight?

Dr. Mehmet Oz, MD
Cardiology (Cardiovascular Disease)
Insulin resistance—in which the body isn't able to use the hormone insulin properly in order to get energy from glucose—can develop as a result of weight gain. That's because putting on pounds means an increase in body fat (adipose tissue). Fat cells are highly active. They produce many different chemicals, including inflammatory compounds, fatty acids and various hormones. These and other chemicals released by fat cells create changes that can result in insulin resistance. Not surprisingly, obese people have a high risk for insulin resistance and type 2 diabetes.

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