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Are there side effects of taking doxycycline hyclate?

Side effects that may occur when taking doxycycline hyclate include: gastrointestinal effects like swallowing difficulties, nausea, vomiting, diarrhea, upset stomach and mouth sores. It may also cause vaginal discharge or itchiness.

Call your doctor immediately if you experience an allergic reaction (hives, itchy rash, facial swelling and difficulty breathing) or these more serious side effects:

  • abdominal pain
  • severe diarrhea
  • appetite loss
  • reduced urination or dark urine
  • blurred vision
  • light sensitivity
  • severe headaches
  • dizziness
  • confusion
  • weakness
  • jaundice
  • chest pain
  • rapid heart rate
  • fever
  • chills
  • body aching, flu-like symptoms
  • soreness in throat
  • severe sunburn
  • joint pain
  • unexplained changes in bruising or bleeding
  • unusual tiredness
  • excessive vaginal discharge or discomfort
  • and skin blistering, peeling or rash

Because other side effects not listed here may occur, you should notify a doctor about any new symptoms you have while taking this medication.  

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.