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The dosage for the SJWE standardized to contain 0.3 percent hypericin and 3 to 5 percent hyperforin is typically 900 mg per day for mild depression and 1,800 mg per day for moderate to severe depression. Initially the dosage was spread out during the day, but recent studies indicate that a single daily dose is preferable.
Adults (18 years and older): Clinical trials have used a range of doses, including 0.17-2.7 milligrams of hypericin by mouth, and 900-1,800 milligrams of St. John's wort extract daily by mouth.
1.5% hyperforin (verum) has been applied to the skin for the treatment of atopic dermatitis.
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