What is the treatment for Kleine-Levin syndrome (KLS)?

There is no definitive treatment for Kleine-Levin syndrome and watchful waiting at home, rather than pharmacotherapy, is most often advised. Stimulant pills, including amphetamines, methylphenidate, and modafinil, are used to treat sleepiness, but may increase irritability and not improve cognitive abnormalities. Due to the similarities between KLS and certain mood disorders, lithium and carbamazepine may be prescribed and, in some cases, have been shown to prevent further episodes. This disorder should be differentiated from cyclic re-occurrence of sleepiness during the premenstrual period in teen-aged girls, which may be controlled with birth control pills. It also should be differentiated from encephalopathy, recurrent depression, or psychosis.

This answer is based on source information from the National Institute of Neurological Disorders and Stroke

Continue Learning about Sleep Disorders

What foods should I avoid if I have trouble sleeping?
Dr. Mehmet Oz, MDDr. Mehmet Oz, MD
Just as there are many foods that help you sleep well, there are also foods to avoid. Refined carboh...
More Answers
How can sleep problems affect children's health?
Dr. Michael Breus, PhDDr. Michael Breus, PhD
For children, the consequences of undiagnosed sleep problems can be serious. Complications to th...
More Answers
Do sleep disorders have more serious consequences for men or women?
Dr. Michael Breus, PhDDr. Michael Breus, PhD
There is evidence that women are in some ways more vulnerable than men to sleep disorders and to...
More Answers
Are sleep disorders serious?
Dr. Jeanne Morrison, PhDDr. Jeanne Morrison, PhD
Some sleep disorders can have little impact on your life, while others can be quite serious. Much de...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.