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Can Zoloft interact with other medications or foods?

The antidepressant Zoloft (sertraline) is not known to interact with foods, but it may interact with other medications. People who are taking another kind of antidepressant known as a monoamine oxidase inhibitor (MAOI) should not take Zoloft, because the combination can trigger a potentially life-threatening condition called serotonin syndrome. Zoloft can also interact with other medications, including:
  • blood thinners
  • other antidepressants and medications for anxiety and mental illness
  • painkillers (such as aspirin, ibuprofen and naproxen)
  • cimetidine (Tagamet)
  • medications to treat Parkinson's disease and seizure
  • medications for irregular heartbeat
  • oral medications for diabetes
  • medications for migraine headaches
  • sedatives, sleeping pills and tranquilizers
People who are taking disulfiram (Antabuse) should not take the liquid Zoloft concentrate, since the concentrate contains alcohol (disulfiram makes you feel sick when you consume alcohol). Tell your doctor about all the medications and supplements you take before starting to take Zoloft.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.