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Who should not take Kalydeco?

People who are taking certain medications or supplements should not take Kalydeco (ivacaftor), a prescription drug to treat a rare form of cystic fibrosis. These include the antibiotics rifampin (Rifamate, Rifater) and rifabutin (Mycobutin) and seizure medications such as phenobarbital, carbamazepine (Tegretol, Carbatrol, Equetro) or phenytoin (Dilantin, Phenytek). These medications may make Kalydeco less effective. St. John’s wort, a popular supplement for depression, can also interact with Kalydeco.

Talk to your doctor about any medications or supplements you take, to find out if you need to make a change before you start taking Kalydeco. You should also talk to your doctor if you have a liver condition, if you are pregnant or plan to become pregnant or if you are breastfeeding, to determine whether it is safe for you to take Kalydeco.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.