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Histamine serves a vital role in normal cycles of sleep and wakefulness -- called circadian rhythms -- that govern our 24-hour day. Histamine is produced in the brain in higher concentrations during the day, which keeps us awake and alert. Levels fall at night. If histamine production is stimulated at night, as is sometimes the case when mosquitoes or spiders bite us, it not only itches, but can keep you awake.
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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.