How does dimenhydrinate treat motion sickness?

Stacy Wiegman, PharmD

Pharmacy

Dimenhydrinate treats motion sickness because it is both an antihistamine and an anticholinergic. Dimenhydrinate works on the brain to block the production of histamine and to reduce spasm activity which lead to the feelings of nausea and dizziness and decreases the chance of vomiting. Dimenhydrinate should be administered at least a half hour before activity or travel to be most effective.

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