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What should I know before treatment with IL-17 inhibitors?

Donna Hill Howes, RN
Family Practitioner

Your doctor will need to test you for tuberculosis before you start taking an IL-17 inhibitor.

Secukinumab and ixekizumab can make Crohn's disease worse. Ixekizumab can make ulcerative colitis worse.

If you have a chronic infection or have had a recurrent infection in the past, secukinumab may not be a good option for you. If you have tuberculosis, you should not take ixekizumab or secukinumab.

An IL-17 inhibitor may not be a good option for you if you are pregnant, planning a pregnancy, or may be pregnant. It is not known if these drugs are safe for pregnant women.

If you are breastfeeding, an IL-17 inhibitor may not be a good option for you. It is not known if these drugs can be passed into breast milk.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.