What is the role of PTEN in prostate cancer?

Marc B. Garnick, MD
Hematology & Oncology
Many men with metastatic prostate cancer are PTEN deficient, meaning that they have a mutation in the PTEN tumor suppressor gene. PTEN normally keeps the cancer-causing PI3K pathway in check, so when PTEN is "lost," cancer cells grow faster. PI3K also activates other genes that seem to play a role in prostate cancer, namely AKT and mTOR.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.