What is the role of PTEN in prostate cancer?

Marc B. Garnick, MD

Hematology & Oncology

Many men with metastatic prostate cancer are PTEN deficient, meaning that they have a mutation in the PTEN tumor suppressor gene. PTEN normally keeps the cancer-causing PI3K pathway in check, so when PTEN is "lost," cancer cells grow faster. PI3K also activates other genes that seem to play a role in prostate cancer, namely AKT and mTOR.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.

Prostate Cancer

One of the most common cancers among men, prostate cancer can be very aggressive and spread to your bones and other organs. Cancer usually develops very slowly in the prostate gland, which produces fluid that helps create a man's semen. If found early, when the cancer is confined only to the gland, prostate cancer is very treatable.

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