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How do castration-resistant and hormone-refractory prostate cancers differ?

Marc B. Garnick, MD
Hematology & Oncology
Many people use "castration-resistant prostate cancer" and "hormone-refractory prostate cancer" interchangeably. Hormone-refractory prostate cancer implies that the cancer no longer responds to hormone therapy, but the fact that prostate cancer responds to drugs like abiraterone and MDV3100 shows that the tumor is still "hormone sensitive." As a result, some experts prefer the term castration-resistant prostate cancer.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.