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How is the antifungal ketoconazole used to treat prostate cancer?

Marc B. Garnick, MD
Hematology & Oncology
In very high doses, the antifungal ketoconazole() (Nizoral) rapidly lowers blood levels of testosterone during the treatment of prostate cancer. It is used with hydrocortisone. Ketoconazole should not be taken with alcohol. The side effects of ketoconazole include nausea, fatigue, swelling, skin rash, abnormal liver function.

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