What are the side effects of progesterone injections?

Using progesterone injections may cause a variety of side effects, ranging from mild to serious. Typical side effects include:

  • nausea
  • tiredness
  • impaired thought
  • lightheadedness
  • acne
  • breast tenderness
  • soreness at the injection point
  • body hair growth and scalp hair loss

More serious side effects include:

  • allergic reactions
  • vision problems
  • jaundice (yellow skin or eyes)
  • dark patches on the skin
  • difficulty breathing
  • difficulty urinating
  • depression
  • swelling in the ankles or feet
  • dark-colored urine
  • severe pain in the jaw, chest, arm, stomach or head
  • fainting
  • unexplained vaginal bleeding
  • loss of strength on one side of your body

Also, progesterone may increase your chance of developing dementia and heart disease. Get medical help immediately if you have any of these more serious side effects.

Continue Learning about Progesterone

What should I know about progesterone injection before using it?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
There are certain precautions you should be aware of before getting a progesterone injection. It...
More Answers
What forms of progesterone are available?
Dr. Michael Roizen, MDDr. Michael Roizen, MD
America is the land of choices -- well, sometimes at least -- and progesterone is no exception. It i...
More Answers
What is the role of progesterone in pregnancy?
Dawn MarcusDawn Marcus
Progesterone prepares the uterus for pregnancy and helps to maintain a healthy pregnancy. The wo...
More Answers
Where can I buy a progesterone cream?
Marcy Holmes, MSN, NPMarcy Holmes, MSN, NP
You can get the low-dose, over-the-counter progesterone cream formulas at most health food stores, o...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.