What hormones does the placenta make or secrete?
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Dr. Damen W. Hershberger, MD
OBGYN (Obstetrician & Gynecologist)

The placenta makes or secretes a number of hormones. Two of the most important hormones are progesterone and human placental lactogen (hPL). The function of these hormones is not fully understood, but progesterone seems to preserve the pregnancy. If progesterone is too low it can be associated with pregnancy loss. The hormone hPL appears to contribute to the growth of the baby. It also appears to cause insulin resistance and to contribute to gestational diabetes.

Besides filtering and exchange nutrients and gases, the placenta also has other duties, including making and secreting many hormones. Some of these include:

  1. Estrogen: In pregnancy, estrogen stimulates the growth of the uterus and improves blood flow between the uterus and placenta. It also preps the breasts to prepare for milk production by enlarging a woman's milk ducts. Peak estrogen secretion happens right before birth.
  2. Progesterone: This hormone helps maintain the inner layer of the uterus to provide support for the developing embryo. It also serves the very important role of quieting the uterine muscle, so the blastocyst can have a safe landing while implanting.
  3. Human Placental Lactogen: Besides helping with milk preparation, this hormone also increases a mom's metabolism during pregnancy (she needs more energy caring for another human, after all).
  4. Human Chorionic Gonadotropin: This hormone stimulates the corpus luteum (the part of the follicle left behind in the ovary) to produce estrogen and progesterone in the first 10 weeks after conception, until the placental cells can do so by themselves. (For this reason, it is also the hormone we check in your urine or blood to determine whether you're pregnant.) Levels of hCG, which have been associated with morning sickness, typically peak toward the end of the first trimester, then decline and level off for the rest of the pregnancy.
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Dr. Nay G. Hoche, MD
OBGYN (Obstetrician & Gynecologist)

The placenta makes several hormones, including estrogen and progesterone, says Nay Hoche, MD, from Medical Center of Trinity. Watch this video to learn what other hormones are produced, as well as what they do.

Continue Learning about Placenta & Fetal Development

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.