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Who should not take Xalkori?

Several groups of people should not take Xalkori (crizotinib), which treats one kind of lung cancer. The drug is not appropriate for all people with advanced non-small cell lung cancer. Xalkori targets a certain change in the anaplastic lymphoma kinase gene, so only those with the abnormal gene benefit from the medicine.

Others who should not take Xalkori include those with a heart rhythm problem known as congenital long QT syndrome, because the drug can worsen the condition. Pregnant women should speak with their doctor to weigh the drug's benefits with the possible harm to the developing fetus.

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