When should I call my doctor if I am taking Zelboraf?

You should call your doctor if any of the following symptoms or side effects become persistent or severe while taking the melanoma drug Zelboraf (vemurafenib):

• fatigue
• body aches and pain
• swelling in your hands, feet, ankles or lower legs
• changes in your sense of taste
• headache
• hair loss
• dry or itchy skin
• diarrhea or constipation
• cough

Get medical attention immediately if you experience:

• difficulty breathing or swallowing
• rapid, irregular or pounding heartbeats
• fainting
• body-wide rash or redness
• hives
• peeling, blistering skin
• fever
• nausea, vomiting or loss of appetite
• pain in the upper right part of your stomach
• yellowing of your skin or eyes
• throat tightness or hoarseness
• swelling of the face, lips or tongue
• blisters or sores in the mouth
• urine turns dark or brown (tea color)

Let your doctor know right away if you notice any new skin growths, a sore or red bump that bleeds or doesn't heal, or changes in an existing mole.