When should I call my doctor if I am taking Xtandi?

You should call your doctor if you are taking Xtandi (enzalutamide), a prescription medication used to treat metastatic castration-resistant prostate cancer, if any of these side effects are severe or don't go away:
  • seizure
  • unconsciousness
  • falls
  • fatigue
  • weakness in your muscles
  • joint pain
  • back pain
  • diarrhea
  • upper or lower respiratory infection
  • blood in your urine
  • hot flashes
  • swelling in your feet, lower legs or ankles
  • headache
  • dizziness
  • inability to sleep
  • cauda equina syndrome (compression of nerve roots in the lower spinal cord)
  • a feeling of tingling, numbness or burning on your skin
  • high blood pressure
  • anxiety
You should also notify your doctor if your partner becomes pregnant while you are taking Xtandi or if you and your partner want to have a baby.

Call your doctor if you want or need to start taking another drug or supplement. A number of drugs and supplements can interact with Xtandi, possibly increasing the risk of side effects or making Xtandi less effective.

If you want to stop taking Xtandi, talk to your doctor first.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.