Do phentermine and topiramate interact with any other medications?

Darragh C. O'Carroll, MD
Emergency Medicine
If you are taking diltiazem, an anticholinergic bronchodilator, a central nervous system depressant, metformin, primidone, rufinamide, a salicylate, a selective serotonin reuptake inhibitor, or valproate, Qsymia may not be a good option for you.

If you are using azelastine nasal spray, a carbonic anhydrase inhibitor, iobenguane I-123, orphenadrine, paraldehyde, thalidomide, or ulipristal, Qsymia can lead to side effects and should be avoided.

Qsymia can cause hormonal contraceptive methods to fail. If you take Qsymia, you should consider using an alternative method of contraception.

You should not take Qsymia while taking an MAO inhibitor or until at least two weeks after stopping MAO inhibitors. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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