Can Zelboraf interact with other medications or foods?

Zelboraf (vemurafenib), a drug used to treat certain types of the melanoma, doesn’t interact with food. However, the drug can interact with many medications. Make sure your doctor and pharmacist has a complete list of all the prescription and nonprescription drugs, herbal remedies, and supplements that you take, especially:
  • antifungals such as itraconazole (Sporanox), ketoconazole (Nizoral) and voriconazole (Vfend)
  • antibiotics such as clarithromycin (Biaxin, in PrevPac), rifampin (Rifadin, in Rifamate, Rifater and Rimactane), rifapentine (Priftin) and telithromycin (Ketek)
  • HIV/AIDS drugs such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase) and rifabutin (Mycobutin)
  • heart medications such as amiodarone (Cordarone) and warfarin (Coumadin, Jantoven)
  • seizure medications such as carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal) and phenytoin (Dilantin, Phenytek)
  • antidepressant, such as nefazodone (Serzone)

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