Can Xalkori interact with other medications or foods?

The cancer drug Xalkori (crizotinib) can interact with many drugs, so inform your doctor of all prescription, over-the-counter and herbal remedies that you are taking. For instance, medications that affect the enzyme CYP3A can influence the absorption of Xalkori. They include:

• HIV/AIDS drugs, such as atazanavir, indinavir, nelfinavir, ritonavir and saquinavir
• medications for infection, like clarithromycin, itraconazole, ketoconazole, telithromycin, troleandomycin and voriconazole
• carbamazepine, phenobarbital, phenytoin, rifabutin and rifampin,
• the herbal remedy St. John's wort

Grapefruit and grapefruit juice can also alter the amount of Xalkori that gets in your blood, so avoid the fruit while taking the medication.

Xalkori may affect the levels of some other drugs you might be taking, such as alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus and tacrolimus.