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Can Qsymia interact with other medications or foods?

The prescription weight-loss drug Qsymia (phentermine and topiramate) is not known to interact with foods, but it can interact with certain other medications. Before you start Qsymia, let your doctor know about all your other medicines (prescription and over-the-counter), as well as any supplements you take.

Taking Qsymia with certain medications can increase the risk of serious side effects. Taking Qsymia within 14 days of taking a monoamine oxidase inhibitor (MAOI) may lead to serious or life-threatening side effects. Other medications that may interact dangerously with Qsymia include:
  • monoamine oxidase inhibitors (MAOIs)
  • acetazolamide (Diamox)
  • amitriptyline
  • antihistamines for allergy, cough and cold
  • atropine (AtroPen)
  • birth control pills
  • carbamazepine (Tegretol)
  • digoxin (Lanoxin)
  • diltiazem (Cardizem)
  • diuretics, such as furosemide (Lasix) or hydrochlorothiazide (Microzide)
  • ipratropium (Atrovent)
  • lithium (Lithobid)
  • methazolamide (Neptazane)
  • phenytoin (Dilantin)
  • pioglitazone (Actos)
  • valproic acid (Depakote)
  • zonisamide (Zonegran)
This medicine may also interact with some medications for:
  • bladder problems
  • depression, anxiety or psychotic disturbances
  • Parkinson's disease
  • stomach problems
  • motion sickness
  • diabetes
  • pain, sleep, or muscle relaxation
  • attention disorders

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.