Advertisement

What Is CBD and Why Are so Many People Using It?

What Is CBD and Why Are so Many People Using It?

Cannabidiol is a growing phenomenon—but does it live up to the hype?

From vitamin store oils to online foot creams, cannabidiol (CBD) can be found just about everywhere these days, in a stunning array of products—and millions of people are getting in on the trend. Based on a January 2019 survey, Consumer Reports estimated that about 64 million Americans tried CBD during the two years prior, often to treat health conditions like insomnia, anxiety or pain.

The problem is, while people take CBD for a multitude of medical issues, there is currently little scientific evidence it actually helps. In some cases, it may even pose safety risks. That’s why healthcare providers (HCP) must be careful about the information they relay to patients—and patients should let their HCPs know if they’re taking CBD.

“Patients are nervous sometimes to tell their physicians that they're using these products, so I encourage them to have that open dialogue with me and I thank them for sharing,” says Tulisa LaRocca, MD, an internist affiliated with JFK Medical Center in Atlantis, Florida. “I urge patients and other healthcare providers to retain their clinical curiosity about CBD, but also a healthy skepticism.”

So, what is CBD, exactly? Do the purported health perks really live up to the hype? And what potential problems with CBD should patients keep in mind? 

The basics of CBD
CBD is a cannabinoid, a chemical compound that comes from the cannabis plant. There are more than 100 known cannabinoids, including CBD and tetrahydrocannabinol (THC), the substance that creates a high when you use marijuana. Unlike THC, CBD has no psychoactive effect, which is part of its appeal. 

Certain varieties of the cannabis plant have lower amounts of THC and higher amounts of CBD. These types are commonly known as hemp, and they’re often used to make CBD products, including oils, sprays, creams and pills.

Currently, the legal status of these and other CBD products is extremely complicated. Though the 2018 Farm Bill legalized hemp on a federal level, state and local regulations vary widely, meaning what’s readily available in Colorado may be unlawful in next-door Nebraska. 

The U.S. Food and Drug Administration (FDA) also restricts how CBD can be advertised and sold. It’s against the law to market CBD in food or as a supplement, for example, and to peddle it across state lines. Importantly, it’s also illegal to push a CBD product as a prevention, treatment or cure for any disease without FDA approval. 

That said, the general enforcement of CBD rules is somewhat lax, and the substance remains widely accessible in much of the U.S., especially once online retailers are taken into account. In many states, there are even brick-and-mortar stores dedicated entirely to CBD goods. “I drive around my area, and I see at least four or five CBD stores on the way to work,” says Dr. LaRocca.

Does CBD really have health benefits?
People take CBD for a wide variety of problems, often without the recommendation of a HCP. “A lot of our patients are using CBD on their own without consulting physicians,” says LaRocca. “The biggest use I hear about is for chronic pain. The second most common would be for anxiety, and the third most common reported to me is for insomnia.” 

Some research hints that CBD has potential for treating these, and perhaps other, health problems. For example, a Neuropsychopharmacology review published online in 2017 found overwhelming evidence that cannabinoids helped block inflammation and pain in rodents. Other small human studies have found that CBD may curb the urge to use heroin, suggesting it could help treat opioid abuse. 

In addition to promising research, there’s also widespread anecdotal support for CBD. No matter the illness, many people report that taking CBD simply helps them feel better. This may be true for some, and it may hint at a possible placebo effect for others—the idea that if people believe something works, it just might help. 

That said, much more CBD research is needed, and there’s currently little concrete scientific proof that it’s an effective therapy for most conditions. In fact, the FDA has approved just one medication containing CBD for the treatment of disease: Epidiolex, for people with Dravet syndrome or Lennox-Gastaut syndrome. “They're rare childhood seizure disorders where children can have multiple seizures in a day,” says LaRocca. “[Epidiolex] has reduced the frequency of seizures.” 

On occasion, a company will market CBD specifically as a cure for serious chronic health problems, including illnesses like cancer and Alzheimer’s disease. But patients must understand that it will not prevent, treat or cure these conditions. 

“If a patient tells me that they've been on the website or spoke to a company that touts CBD as being a cure for any disease—cancer, neurodegenerative, whatever—I tell them to beware,” says LaRocca. Companies making these claims put patient lives at risk, since sick people may use CBD instead of seeking proven medical care. 

Other possible downsides of CBD
In general, CBD is considered safe to use in the short-term for most people, and there’s little evidence you can abuse or become dependent on it. However, there are risks of side effects, including nausea, fatigue, irritability, low blood pressure, sleepiness, dry mouth and lightheadedness. 

CBD may also interact negatively with other medications, supplements and even foods; fattier meals and snacks can increase its absorption and effects. What’s more, not much is known about how CBD affects certain populations, including pregnant women, children and older adults. The FDA strongly advises pregnant and nursing women to avoid CBD.

That’s not all. Due in large part to its relative newness, many experts have unresolved questions and concerns about the compound, including its:

  • Long-term safety: CBD’s effects over time remain unclear. For instance, there are some indications it can lead to liver injury in certain people. 
  • Lack of dosing guidelines: There’s little professional medical guidance regarding how much CBD to take for any given condition, and how the amount might vary depending on the form of CBD. “One dose is not a one-dose-fits-all,” says LaRocca. “It's very different dosages for different conditions and for each individual.”
  • Labeling inaccuracies: Since the FDA doesn’t generally police the purity and safety of CBD products, labels aren’t guaranteed to be accurate. There may be unlisted additional ingredients, including THC, or the listed amount of CBD may be incorrect. “There have been a lot of companies that will sell CBD, and then when the patients have had it analyzed by a third party, there's very little CBD in there,” says LaRocca.

Despite these risks, many people decide to go ahead with CBD anyway. In these cases, LaRocca advises patients to exercise caution and take a conservative approach. When her patients use CBD, she recommends starting with a low dose, slowly working up to a dose that’s effective, and monitoring progress. 

“If you're taking it for pain, see how you feel with your pain,” she says. “Keep a log and document how you feel. If you're using it for sleep, document how many hours you're sleeping. If you're using it for anxiety, document how you're feeling with your anxiety.”

To avoid issues with labeling errors, she also recommends asking product manufacturers to provide a third-party evaluation of CBD content. “A reputable company should have no problem showing you that,” she explains.

Ultimately, CBD requires plenty of additional research before we more fully understand its capabilities and drawbacks. For these reasons, it’s always best to speak with an HCP before trying a CBD product. Until then, as LaRocca says, be curious, be skeptical—and go to your provider with questions. 

Medically reviewed in October 2019.

Sources:
Gill, Lisa. “CBD Goes Mainstream.” Consumer Reports. April 2019.
UCLA Health. “Cannabis and its Compounds.”
Harvard Health Publishing” “Cannabidiol (CBD) — what we know and what we don’t.”
National Cancer Institute. “Cannabis and Cannabinoids (PDQ®)–Patient Version.”
Medline Plus. “Cannabidiol (CBD).”
Oregon State University Extension Service. “What is Industrial Hemp?”
U.S Food and Drug Administration (FDA). “Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD),” “What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD,” “FDA Regulation of Cannabidiol (CBD) Products,” “Statement from FDA Commissioner Scott Gottlieb, M.D., on signing of the Agriculture Improvement Act and the agency’s regulation of products containing cannabis and cannabis-derived compounds,” “FDA is Committed to Sound, Science-based Policy on CBD,” “What You Should Know About Using Cannabis, Including CBD, When Pregnant or Breastfeeding,” “Warning Letters and Test Results for Cannabidiol-Related Products.”
VanDolah, Harrison J. et al. Clinicians’ Guide to Cannabidiol and Hemp Oils. Mayo Clinic Proceedings. Volume 94, Issue 9, 1840 – 1851.
Donvito G, Nass SR. et al. The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology. 2018 Jan;43(1):52-79.
UpToDate.com. “Seizures and epilepsy in children: Refractory seizures and prognosis.”
Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Labeling Accuracy of Cannabidiol Extracts Sold Online. JAMA. 2017;318(17):1708–1709.

Ask the Doctors: How to Choose the Right Medications—For You and Your Pet
Ask the Doctors: How to Choose the Right Medications—For You and Your Pet
Q: I need to change birth control pills because the one I’m taking is giving me headaches. What’s the best way to find a new pill and do I need a mont...
Read More
Will I gain weight if I stop taking prescription stimulants?
Howard J. Shaffer, PhDHoward J. Shaffer, PhD
Weight gain is often a problem when people stop taking stimulants. If you're overweight or have ...
More Answers
What are possible side effects of Stribild?
Donna Hill Howes, RNDonna Hill Howes, RN
Side effects may include anxiety, depression, dizziness, fatigue, fever, headache, abnormal dreams, ...
More Answers
What are the Most Common Prescription Drugs That Cause Side Effects?
What are the Most Common Prescription Drugs That Cause Side Effects?