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What are the side effects of oxacillin?

Seek immediate medical attention by calling 911 if you experience symptoms of black-out or convulsive seizures, agitation, confusion or a potentially fatal allergic reaction to oxacillin, characterized by difficulty breathing, hives, rash, itching, tight chest, a dangerous drop in blood pressure or swelling of the mouth, tongue, lips or face. Such a reaction usually occurs in the first 20 minutes after taking oxacillin, but can happen from 48 hours to a month after the medication is administered.

Similarly delayed side effects of taking oxacillin include:

  • fever
  • malaise
  • urticaria
  • myalgia
  • arthralgia
  • abdominal pain
  • nausea
  • vomiting
  • diarrhea
  • stomatitis
  • black or hairy tongue
  • gastrointestinal irritation

Call your doctor if you experience any of these symptoms. Call your doctor right away if you experience any other serious side effects, including:

  • sore throat
  • headaches
  • watery or bloody diarrhea
  • flu-like symptoms (fever, chills, body aches)
  • easy bruising or bleeding
  • unusual weakness
  • diminished or no urine
  • unusual thoughts or behavior
  • a severe rash with blistering, peeling and redness


Less serious side effects include:

  • nausea
  • vomiting
  • stomach pain
  • vaginal itching or discharge
  • headaches

Call your doctor to discuss treatment for these symptoms.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.