Can I take alpha blockers and 5-alpha-reductase inhibitors if I have BPH?

Marc B. Garnick, MD
Hematology & Oncology
Because alpha blockers and 5-alpha-reductase inhibitors work differently in the treatment of benign prostatic hyperplasia (BPH), or prostate enlargement, researchers hypothesized that taking both types of medication might be more effective for controlling symptoms of BPH than taking just one. The Medical Therapy of Prostatic Symptoms (MTOPS) trial found that using finasteride in combination with the alpha blocker doxazosin helped slow progression of BPH by 66%, better than either drug alone. The trial found that the combination of dutasteride and tamsulosin resulted in significantly greater improvements in symptoms, such as improved urinary flow, than taking either drug alone.

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