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How is bone formed and broken down?

David Slovik, MD
Endocrinology Diabetes & Metabolism
Bone is constantly being constructed and demolished. During resorption, cells known as osteoclasts break down bone, releasing calcium into the bloodstream. The trenches that are left behind are then filled in by construction cells known as osteoblasts. The osteoblasts release collagen into these troughs and eventually evolve into structural bone cells, or osteocytes. Once these osteocytes mix together with calcium, phosphate, and other minerals to form a cement-like substance known as hydroxyapatite, the process of replacing the lost bone is complete.

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