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What are the grades of Pancreatic Intraepithelial Neoplasia lesions?

John A. Chabot
Endocrinology Diabetes & Metabolism
There are several grades of Pancreatic Intraepithelial Neoplasia (PanIN) lesions. As the grades progress, the lesions become more severe and more direct indicators of pancreatic cancer. PanIN-1A are the most benign types of PanIN lesions and PanIN-3 are the most severe. PanIN-3 lesions show a high level of dysplasia, or cellular abnormalities, and often evolve into pancreatic cancer.

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