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How does oxycodone interact with other drugs or food?

Central nervous system (CNS) depressants (drugs that make you drowsy) can increase the effects of oxycodone. These medications include: antihistamines and drugs for allergies or colds, sedatives, other prescription pain medicine or narcotics, medicine for seizures, muscle relaxants or anesthetics. If you are taking macrolide antibiotics (such as erythromycin), azole-antifungal agents (such as ketoconazole) or protease inhibitors (such as ritonavir), you may have more side effects from oxycodone.
 
Taking rifampin, carbamazepine or phenytoin may make oxycodone less effective. Let your doctor know if you are using pentazocine (Talwin), nalbuphine (Nubain), butorphanol (Stadol) or buprenorphine (Buprenex, Subutex). You may not be able to use oxycodone, or you may just need a dosage adjustment or special tests to monitor your progress.
 
Before you begin taking oxycodone, tell your doctor about any other medications or supplements that you take, including vitamins, minerals, herbal remedies and over-the-counter medications. Do not start using a new medication without first alerting your doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.