Can I use Roxicodone if I am taking CYP3A4 inducers?

The package insert for the prescription pain medication Roxicodone (oxycodone) doesn't warn users to avoid CYP3A4 inducers -- drugs or other substances that increase the activity of an enzyme (called CYP3A4) needed to break down certain drugs. That enzyme is involved in processing Roxicodone so, in theory, taking a CYP3A4 inducer at the same time as Roxicodone could cause blood levels of the pain reliever to drop too quickly, making it less effective. However, scientists are still learning about the relationship between CYP3A4 inducers and other medications. To be on the safe side, tell your doctor about all your medications, including dietary supplements and herbal remedies, before taking Roxicodone.