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What causes ovarian germ cell tumors?

In general, ovarian germ cell tumors develop when the DNA in the cells in the ovary changes or mutates. Then the cells start to grow and divide at a faster rate than cells in normal tissue. Some of the genes involved are proto-oncogenes, which normally control cell growth and division. Mutated proto-oncogenes are called oncogenes. KIT is one such proto-oncogene that when mutated allows for abnormal growth and division in ovarian germ cells and the formation of an ovarian germ cell tumor. KIT mutations are associated with dysgerminomas, the most common type of germ cell tumor.

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What is an ovarian germ cell tumor?
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Ovarian germ cell tumors form when germ cells in the ovary become abnormal and begin to grow and div...
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Are ovarian germ cell tumors serious?
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Ovarian germ cell tumors can be serious, particularly when they are not diagnosed and treated early....
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Are there different types of ovarian germ cell tumors?
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Yes, there are several different types of ovarian germ cell tumors. Dysgerminomas account for 35-50 ...
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What is the rate of incidence of ovarian germ cell tumors?
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The age adjusted rate of incidence of ovarian germ cell tumors is 0.41 per 100,000. Dysgerminomas ar...
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