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What is the role of uPAR in the diagnosis and prognosis of ovarian cancer?

David A. Fishman, MD
Gynecologic Oncology
UPAR is urokinase-type plasminogen activator receptor. Its truncated forms have been evaluated with regard to differentiating malignant from benign adnexal masses and therefore as a potential biomarker (characteristic used in screening, early diagnosis, prognosis, tracking treatment response or recurrence of disease) in ovarian cancer. Urokinase plasminogen activator (uPA) has been found to be involved in tumor angiogenesis, development, inflammation and metastasis.

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