What is the role of VCAM-1 in ovarian cancer?

David A. Fishman, MD on behalf of The Mount Sinai Health System

Gynecologic Oncology

VCAM-1 is a receptor on the surface of activated endothelial and mesothelial cells. In instances of inflammation, it promotes white blood cell attachment and extravasation. There are reports of it being involved in metastasis of ovarian cancer. The effects of cytokines promoting angiogenesis have been shown to be potentiated by VCAM-1 in endothelial cells. As a soluble form of VCAM-1 is released from endothelial cells, it may prove useful in detecting early or pre-clinical ovarian cancer.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.