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VCAM-1 is a receptor on the surface of activated endothelial and mesothelial cells. In instances of inflammation, it promotes white blood cell attachment and extravasation. There are reports of it being involved in metastasis of ovarian cancer. The effects of cytokines promoting angiogenesis have been shown to be potentiated by VCAM-1 in endothelial cells. As a soluble form of VCAM-1 is released from endothelial cells, it may prove useful in detecting early or pre-clinical ovarian cancer.
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