A Answers (1)
Insulin-like growth factor binding protein 3 (IGFBP-3) is involved in the suppression of mitogenesis and regulation of apoptosis. Forty-four percent of epithelial ovarian cancer showed methylation of this genes promoter region leading to a decreased detectable level of IGFBP in the serum. Overall survival was found to be associated with elevated levels of methylation. Additionally elevated levels are associated with early staged disease.
This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.