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Insulin-like growth factor binding protein 3 (IGFBP-3) is involved in the suppression of mitogenesis and regulation of apoptosis. Forty-four percent of epithelial ovarian cancer showed methylation of this genes promoter region leading to a decreased detectable level of IGFBP in the serum. Overall survival was found to be associated with elevated levels of methylation. Additionally elevated levels are associated with early staged disease.