What is the role of insulin-like growth factor (IGF) in ovarian cancer?

David A. Fishman, MD on behalf of The Mount Sinai Health System

Gynecologic Oncology

Insulin-like growth factor (IGF) I and II and their binding protein constitute a point of cell proliferation and survival regulation. That being the case, these proteins may play a role in carcinogenesis and progression of tumors. Ovarian cancer diagnosis at later stages and poor prognoses have been associated with IGF-II expression. For example, IGF-II has been reported to have involvement in taxol resistance and shortening of disease-free interval.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.