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What is the role of insulin-like growth factor (IGF) in ovarian cancer?

David A. Fishman, MD
Gynecologic Oncology
Insulin-like growth factor (IGF) I and II and their binding protein constitute a point of cell proliferation and survival regulation. That being the case, these proteins may play a role in carcinogenesis and progression of tumors. Ovarian cancer diagnosis at later stages and poor prognoses have been associated with IGF-II expression. For example, IGF-II has been reported to have involvement in taxol resistance and shortening of disease-free interval.

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