What is the role of EGFR in ovarian cancer?

David A. Fishman, MD
Gynecologic Oncology
Ovarian tumors overexpress EGFR (epidermal growth factor receptor). The EGFR gene is estimated to be overexpressed in 10% to 20% of ovarian cancers, while minimal increases are seen in 43% of cases. It is thought that the factor that determines overall and disease-free survival is the EGF receptor (EGF-R). Increased expression of EGF receptor is associated with poorer outcomes as this is seen with more aggressive entities.

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