What is the role of EGFR in ovarian cancer?

David A. Fishman, MD on behalf of The Mount Sinai Health System

Gynecologic Oncology

Ovarian tumors overexpress EGFR (epidermal growth factor receptor). The EGFR gene is estimated to be overexpressed in 10% to 20% of ovarian cancers, while minimal increases are seen in 43% of cases. It is thought that the factor that determines overall and disease-free survival is the EGF receptor (EGF-R). Increased expression of EGF receptor is associated with poorer outcomes as this is seen with more aggressive entities.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.