What is the role of EGFR in ovarian cancer?

David A. Fishman, MD on behalf of The Mount Sinai Health System

Gynecologic Oncology

Ovarian tumors overexpress EGFR (epidermal growth factor receptor). The EGFR gene is estimated to be overexpressed in 10% to 20% of ovarian cancers, while minimal increases are seen in 43% of cases. It is thought that the factor that determines overall and disease-free survival is the EGF receptor (EGF-R). Increased expression of EGF receptor is associated with poorer outcomes as this is seen with more aggressive entities.

Continue Learning about Ovarian Cancer

How Is Ovarian Cancer Diagnosed and Treated?

A mass on the ovary is usually detected through transvaginal ultrasound, but needs further testing before diagnosis, says Audra Moran. In this video s...

David A. Fishman, MD

Knocking down the MUC16 gene abolishes the cells' ability to form tumors. Larger tumor formation...

Ovarian Cancer Research Fund (OCRF)

Symptoms of ovarian cancer can be vague and not always gynecologic, such as: a swollen or bloated...

What Are Risk Factors for Ovarian Cancer?

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.