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Ovarian tumors overexpress EGFR (epidermal growth factor receptor). The EGFR gene is estimated to be overexpressed in 10% to 20% of ovarian cancers, while minimal increases are seen in 43% of cases. It is thought that the factor that determines overall and disease-free survival is the EGF receptor (EGF-R). Increased expression of EGF receptor is associated with poorer outcomes as this is seen with more aggressive entities.
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