Is ovarian cancer associated with any genetic diseases?

Diana Meeks
Diana Meeks on behalf of Sigma Nursing
Family Practitioner

Hereditary nonpolyposis colorectal cancer (HPNCC), Peutz-Jeghers Syndrome, and Cowden's disease may be associated with ovarian cancer. MLH1, MLH2, and PMS1 are three genes which may be mutated in those with HPNCC. These genes allow cells to repair mistakes that occur in DNA during division. When they do not function properly, DNA mutations may occur, leading to abnormal cell growth and division, and ultimately, cancer.

Ovarian cancer is associated with BRCA1 and BRCA2 genetic mutations. Ovarian cancer is also associated with Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer.

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