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How is apolipoprotein A1 (ApoA1) associated with ovarian cancer?

David A. Fishman, MD
Gynecologic Oncology
Apolipoprotein A1 (ApoA1) is one of the constituents of the cholesterol removing high-density lipoprotein; 70% of circulating ApoA1 is made by the liver and 30% by the small intestines. It is made up of 243 amino acids. Research has shown that exogenous ApoA1 prevents tumor development in mice, while lowered APoA1 levels are associated with ovarian cancer. ApoA1 has been shown to have anti-inflammatory and antioxidant capabilities in addition to counteracting atherogenesis. This is important, as other factors known to be associated with tumorigenesis and cancer progression have been found to be elevated in a number of cancers including ovarian. Additionally, these factors may be produced by the tumors and/or the tumor microenvironment.

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