Can a DNA microarray help diagnose and monitor ovarian cancer?

David A. Fishman, MD on behalf of The Mount Sinai Health System

Gynecologic Oncology

Both diagnostic and prognostic information for ovarian cancer have been obtained by microarrays (supporting material such as a slide made of glass or plastic, minute beads, or microchip with different nucleic acid probes, or proteins chemically attached in a regular pattern). For example, one author identified hundreds of genes that are associated with cisplatin resistance in ovarian cancer, another found genes encoding secretory proteins that are over-expressed in ovarian cancer cell lines using complementary DNA (cDNA) microarrays, a third reported finding 285 different expressions of genes using cDNA-DASL from formalin-fixed paraffin embedded samples.

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