How do bisphosphonates work to keep bones strong?

Audrey K. Chun, MD
Geriatric Medicine
Healthy bones are in a state of continuous breakdown and rebuilding. This process is called remodeling and is performed by specialized cells called osteoclasts, which resorb (break down) old bone, and osteoblasts, which form new bone.

Bisphosphonates work by interfering with the action of osteoclasts, meaning that less bone is broken down and bone density is maintained.

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