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Do any other drugs interact with nonsteroidal anti-inflammatory drugs?

Donna Hill Howes, RN
Family Practitioner

If you are taking methotrexate, NSAIDs can lead to serious side effects and should be avoided.

If you are taking a beta blocker, a serotonin reuptake inhibitor, omacetaxine, or pimozide, NSAIDs can lead to side effects and should be avoided.

If you are taking diflunisal, indomethacin may not be a good option for you.

If you are taking dimethyl sulfoxide, sulindac may not be a good option for you.

If you are taking ritonavir, piroxicam may not be a good option for you.

Some combinations of NSAIDs can cause serious side effects.

An NSAID may not be a good option for you if you are taking any of the following medications:

  • an ACE inhibitor
  • aliskiren
  • an aminoglycoside antibiotic
  • an anticoagulant
  • an antiplatelet agent
  • bisphosphonate
  • a corticosteroid
  • cyclosporine
  • deferasirox
  • desmopressin
  • a diuretic
  • erlotinib
  • a fluoroquinolone antibiotic
  • haloperidol
  • a hydantoin anticonvulsant
  • ibritumomab
  • ibrutinib
  • lithium
  • probenecid
  • tacrolimus
  • tenofovir
  • a thrombolytic drug
  • tositumomab
  • triamterene 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.