Can ranibizumab help treat wet age-related macular degeneration?

Jeffrey S. Heier, MD
Ranibizumab (Lucentis) arrests wet age-related macular degeneration (AMD) in most people and can dramatically improve vision in about 30% to 40% of those who take it, according to the results of two large randomized clinical trials reported in The New England Journal of Medicine.

In one study, involving 716 people with wet AMD, the disease stabilized in more than 94% of those who received injections of ranibizumab, compared with 62% of those who received sham injections. Vision actually improved three lines or more on the eye chart in 25% to 34% of those receiving ranibizumab, depending on the dose, compared with only 5% of those who received sham injections.

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