Who should not take Nucynta?

People who are allergic to tapentadol, the active ingredient in Nucynta, should not take Nucynta. People who have severe bronchial asthma or respiratory depression shouldn't take it, nor should people with a certain bowel problem. Talk to your doctor before beginning Nucynta if you are pregnant or planning to become pregnant or have breathing problems or liver, kidney, bowel, gallbladder or pancreas problems. Talk to your doctor before taking Nucynta if you take MAO inhibitors.