Can Ultram interact with other medications or foods?

The prescription pain medication Ultram (tramadol) is not known to interact with foods, but it can interact with many other medications. Before you start Ultram, let your doctor know about all other prescription and over-the-counter drugs, vitamins and herbal supplements you are taking.

Taking Ultram with certain medications can increase the risk of serious or life-threatening side effects, such as seizures and a group of symptoms that together are called serotonin syndrome. These medications include:
  • certain antibiotics, such as erythromycin and linezolid
  • certain antifungals, such as ketoconazole
  • triptans
  • quinidine
  • rifampin
  • lithium
  • the supplement St. John's wort
  • selective serotonin reuptake inhibitors (SSRIs), such as citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline 
  • monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, selegiline and tranylcypromine
  • tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline and trimipramine
Other medicines that affect your central nervous system or cause sleepiness -- such as other opioid pain medicines, sleeping pills, antianxiety medicines, muscle relaxants, tranquilizers or sedative hypnotics, antipsychotics, antiseizure medicines, antinausea medicines or general anesthetics -- may make the side effects of Ultram more severe.

In addition, Ultram may interfere with the actions of the heart medication digoxin and the blood thinner warfarin.

Avoid drinking alcohol while taking Ultram because it increases the risk of serious side effects of the medicine.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.