What is the difference between intravenous and liquid methadone?

There is a major difference between methadone taken intravenously versus methadone swallowed in liquid form. Taking methadone intravenously is how people are able to abuse it, and it does produce a rapid onset of the sought-after rush on the opioid receptors. If it is swallowed in the liquid form, most of it gets taken up by the liver and is released steadily at a slow rate over the next 24 to 36 hours. Therefore, you don’t get that rush or high, but you get a steady level of activation from the μ-opioid receptors so that you don’t go into the withdrawal sickness. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.