Does morphine sustained release interact with other medications?

Stacy Wiegman, PharmD

Pharmacy

The side effects of morphine sulfate sustained release are intensified if you have taken monoamine oxidase inhibitors (MAOIs) within the preceding two weeks. Do not use morphine sustained release along with other drugs that make you sleepy, such as other narcotic medications, sedatives, tranquilizers, muscle relaxants or medications that can slow your breathing. Mixing these drugs can lead to dangerous side effects. Using pentazocine, nalbuphine, butorphanol and buprenorphine may contraindicate taking morphine sustained release or may require special testing and dosage adjustments. Inform your doctor about all other medications, over-the-counter drugs, vitamins, supplements and herbs you are taking. Alcohol combined with morphine sustained release can cause dangerous side effects or death. Check all product labels to make certain they do not contain any alcohol.

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