Does fentanyl interact with other medications or food?

Yes. When you are taking any form of fentanyl, tell your doctor if you take these drugs, as they may interact with fentanyl: antihistamines, carbamazepine (Carbatrol, Equetro, Tegretol), muscle relaxants, other pain medications, phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate), sedatives, sleeping pills or tranquilizers. Tell your doctor if you are taking, or have stopped taking within the last 14 days, any of the following: monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar) and tranylcypromine (Parnate).

When using the skin patch form of fentanyl, tell your doctor if you take these drugs as they may interact with fentanyl: amiodarone (Cordarone), antidepressants, cimetidine (Tagamet), diltiazem, erythromycin (E-Mycin, Erythrocin), fluvoxamine, medications for anxiety, medications for cough, cold or allergies, medications for nausea, nevirapine (Viramune), phenobarbital or verapamil (Calan, Verelan). When using the tablet, lozenge or ingestible film form of fentanyl, tell your doctor if you take these drugs, as they may interact with fentanyl: buprenorphine (Buprenex, Subutex, in Suboxone), butorphanol (Stadol), medications for mental illness; medications for nausea, nalbuphine (Nubain), naloxone (Narcan), nalmefene (Revex) or pentazocine (Talwin). When taking any of these drugs, your doctor may need to adjust dosing instructions, change medications or monitor you closely for side effects. If you use the herbal supplement St. John's Wort, tell your doctor; it may affect how fentanyl works. Also, do not eat grapefruit or drink grapefruit juice while on this drug; it may affect the effectiveness of fentanyl.