Can I use Ryzolt if I am taking monoamine oxidase inhibitors (MAOIs)?

It's important to talk to your doctor before taking the long-acting prescription pain medication Ryzolt (tramadol extended-release tablets) if you use a monoamine oxidase inhibitor (MAOI). Combining these drugs may increase the risk of seizures, as well as a rare but serious condition called serotonin syndrome. Your doctor may not prescribe an alternative to one of the drugs; if you do need to combine these drugs, your doctor may want to closely monitor your treatment, particularly when you start Ryzolt and when your dose is changed.