Can I use Rybix ODT if I am taking SSRIs?

Stacy Wiegman, PharmD

Pharmacy

Taking Rybix ODT (tramadol) while on a selective serotonin reuptake inhibitor, or SSRI, may pose a serious threat to your health. Rybix ODT is a pain reliever that belongs to a class of medications called opioid analgesics. SSRIs are a certain type of antidepressant; common SSRIs include citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil) and sertraline (Zoloft). Combining Rybix ODT and an SSRI can increase the risk for seizures, as well as a serious condition called serotonin syndrome. Serotonin syndrome can result in hallucinations, loss of muscle coordination, gastrointestinal problems and other serious complications. In extreme cases, serotonin syndrome can induce a coma or be fatal. Be sure your doctor knows about all medications you use before you begin taking Rybix ODT.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.