Can I use Nucynta if I am taking MAO inhibitors?

Stacy Wiegman, PharmD

Pharmacy

You should not take the pain medication Nucynta (tapentadol) if you're using an antidepressant from the group called monoamine oxidase inhibitors (MAOIs) or if you've taken one in the past 14 days. Both Nucynta and MAOIs increase your body’s level of the chemical norepinephrine. In combination they may cause high blood pressure and other cardiovascular problems. MAOIs include: isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Emsam, Eldepryl, Zelapar) and tranylcypromine (Parnate).

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.